Forskning om mangostan/xanton
Mangostanfrukten er en eksepsjonelt næringsrik frukt med en sensasjonell smak. Det er mange bestanddeler i mangostan som er ernæringsmessig gunstige. De viktigste elementene—xantoner, er svært stabile og robuste molekyler som viser biologisk aktivitet. Mangostanfrukten inneholder ca. 40 kjente xantoner, og de fleste av disse finnes i høy konsentrasjon i skallet. Aktive vekstemner som kalles flavonoler gir fordeler for kroppen. De to flavonolene som hovedsakelig er funnet i mangostan er catechiner (finnes i grønn te) og proantocyanidiner (finnes i druekjerner). Mens vitenskapen fremdeles prøver å evaluere anvendelsen av mangostan viser forskning at mangostans kraftige fytokjemikalier så langt er svært lovende. Mangostan har blitt studert i 150 år, resulterte i over 110 studier publisert i vitenskapelige tidsskrifter, og studier som inkluderte alle systemer i kroppen. Studier av mangostan øker eksponentielt med 15 stykker opp til 1980, 30 i 1990-årene og allerede xx siden 2000.
Siste forskning om frukten mangostan:
2010:
24-2010: Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana.
23-2010: The classical drug discovery approach to defining bioactive constituents of botanicals.
22-2010: Xanthones, biflavanones and triterpenes from Pentadesma grandifolia (Clusiaceae): structural determination and bioactivity.
21-2010: Effect of mangosteen (Garcinia mangostana L.) extracts as a feed additive on growth and hematological parameters of African catfish (Clarias gariepinus) fingerlings.
20-2010: Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana.
19-2010: alpha-Mangostin Suppresses Phorbol 12-myristate 13-acetate-Induced MMP-2/MMP-9 Expressions via alphavbeta3 Integrin/FAK/ERK and NF-kappaB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells.
18-2010: Antioxidant, free radical-scavenging activity and cytotoxicity of different solvent extracts and their phenolic constituents from the fruit hull of mangosteen (Garcinia mangostana).
17-2010: Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods.
16-2010: Removal of Pb(II), Cd(II) and Co(II) from aqueous solution using Garcinia mangostana L. fruit shell.
15-2010: The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction.
14-2010: Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia.
13-2010: Anti-Acne-Inducing Bacterial Activity of Mangosteen Fruit Rind Extracts.
12-2010: Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines.
11-2010: Enhanced growth of lactobacilli in soymilk upon immobilization on agrowastes.
10-2010: alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells.
9-2010: Molecular Diversity of Fungal Endophytes Isolated from Garcinia mangostana and Garcinia parvifolia.
8-2010: Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants.
7-2010: The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor.
6-2010: Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography.
5-2010: Xanthones from Mangosteen Inhibit Inflammation in Human Macrophages and in Human Adipocytes Exposed to Macrophage-Conditioned Media.
4-2010: Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana.
3-2010: Total Synthesis of Tovophyllin B.
2-2010: Potential of Xanthones from Tropical Fruit Mangosteen as Anti-cancer Agents: Caspase-Dependent Apoptosis Induction In Vitro and in Mice.
1-2010: New medicinal properties of mangostins: Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.
2009
27. Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy.
26. Effects of alpha-mangostin on mitochondrial energetic metabolism.
25. Effects of fruit extracts on the formation of acrylamide in model reactions and fried potato crisps.
24. Renoprotection by alpha-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity.
23. Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study.
22. Cytotoxic Xanthone Constituents of the Stem Bark of Garcinia mangostana (Mangosteen).
21. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans.
20. Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana.
19. Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy.
18. Activity of Mangosteen Xanthones and Teleocidin A-2 in Death Receptor Expression Enhancement and Tumor Necrosis Factor Related Apoptosis-Inducing Ligand Assays (#).
17. Antifungal activity of alpha-mangostin against Candida albicans.
16. Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin.
15. Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial.
14. Panaxanthone Isolated from Pericarp of Garcinia mangostana L. Suppresses Tumor Growth and Metastasis of a Mouse Model of Mammary Cancer.
13. Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity.
12. In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract.
11. Electrospun poly (vinyl alcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen.
10. Mangosteen (Garcinia mangostana).
9. Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells.
8. Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes.
7. Anti-cancer effects of xanthones from pericarps of mangosteen.
6. A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening.
5. Validation of LC for the Determination of alpha-Mangostin in Mangosteen Peel Extract: A Tool for Quality Assessment of Garcinia mangostana L.
4. The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.
3. XanGo® Juice’s Effect on Inflammation Reduction.
2. Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells.
1. alpha-Mangostin Suppresses PC-3 Human Prostate Carcinoma Cell Metastasis by Inhibiting Matrix Metalloproteinase-2/9 and Urokinase-Plasminogen Expression through the JNK Signaling Pathway.
2008
1. Centrifugal partition chromatography directly interfaced with mass spectrometry for the fast screening and fractionation of major xanthones in Garcina mangostana.
2. ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons.
3. Antibacterial Activity of Thai Medicinal Plants against Methicillin-resistant Staphylococcus aureus.
4. Pichia garciniae sp. nov., isolated from a rotten mangosteen fruit (Garcinia mangostana L., Clusiaceae).
5. Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment.
6. Thin-layer chromatography-densitometric analysis of alpha-mangostin content in Garcinia mangostana fruit rind extracts.
7. Medicinal properties of mangosteen (Garcinia mangostana).
8. Xanthones from the Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity.
9. Electrospun poly(vinyl alcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen.
10. Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.
11. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana.
12. Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats.
13. Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
2007
1. Inhibitory effects of xanthone on paraquat- and NaNO(2)-induced genotoxicity in cultured cells.
2. Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.
3. Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).
4. Assay-guided Fractionation Study of alpha-Amylase Inhibitors from Garcinia mangostana Pericarp.
5. Anti-inflammatory activity of mangostins from Garcinia mangostana.
6. Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
7. Oligomeric Proanthocyanidins from Mangosteen Pericarps.
8. Characterized mechanism of alpha-mangostin-induced cell death: Caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells.
9. Comparative study of health properties and nutritional value of durian, mangosteen, and snake fruit: experiments in vitro and in vivo.
10. Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
11. HPLC analysis of selected xanthones in mangosteen fruit.
osv.
For å lære mer om xanthoner gå til www.pubmed.com og skriv inn xanthones. Eller lær mer om frukten mangostan (også PubMed).
XanGo gir ingen medisinske påstander om sitt produkt. Det kan heller ingen uavhengige distributører gjøre. XanGo er en velsmakende drikk laget av hele mangostanfrukten sammen med andre frukter som gir den unike smaken. Hovedingrediensen er frukten mangostan. Mangostan inneholder svært viktige fytokjemikalier som kalles xanthoner.
